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(Image caption: A solar flare erupts on the far right side of the sun, in this image captured by NASA’s Solar Dynamics Observatory. The flare peaked at 6:34 p.m. EDT on March 12, 2014. Credit: NASA)
Some Astronauts at Risk for Cognitive Impairment
Johns Hopkins scientists report that rats exposed to high-energy particles, simulating conditions astronauts would face on a long-term deep space mission, show lapses in attention and slower reaction times, even when the radiation exposure is in extremely low dose ranges.
The cognitive impairments — which affected a large subset, but far from all, of the animals — appear to be linked to protein changes in the brain, the scientists say. The findings, if found to hold true in humans, suggest it may be possible to develop a biological marker to predict sensitivity to radiation’s effects on the human brain before deployment to deep space. The study, funded by NASA’s National Space Biomedical Research Institute, is described in the April issue of the journal Radiation Research.
When astronauts are outside of the Earth’s magnetic field, spaceships provide only limited shielding from radiation exposure, explains study leader Robert D. Hienz, Ph.D., an associate professor of behavioral biology at the Johns Hopkins University School of Medicine. If they take space walks or work outside their vehicles, they will be exposed to the full effects of radiation from solar flares and intergalactic cosmic rays, he says, and since neither the moon nor Mars have a planet-wide magnetic field, astronauts will be exposed to relatively high radiation levels, even when they land on these surfaces.
But not everyone will be affected the same way, his experiments suggest. “In our radiated rats, we found that 40 to 45 percent had these attention-related deficits, while the rest were seemingly unaffected,” Hienz says. “If the same proves true in humans and we can identify those more susceptible to radiation’s effects before they are harmfully exposed, we may be able to mitigate the damage.”
If a biomarker can be identified for humans, it could have even broader implications in determining the best course of treatment for patients receiving radiotherapy for brain tumors or identifying which patients may be more at risk from radiation-based medical treatments, the investigators note.
Previous research has tested how well radiation-exposed rats do with basic learning tasks and mazes, but this new Johns Hopkins study focused on tests that closely mimic the self-tests of fitness for duty currently used by astronauts on the International Space Station prior to mission-critical events such as space walks. Similar fitness tests are also used for soldiers, airline pilots and long-haul truckers.
In one such test, an astronaut sees a blank screen on a handheld device and is instructed to tap the screen when an LED counter lights up. The normal reaction time should be less than 300 milliseconds. The rats in the experiment are similarly taught to touch a light-up key with their noses and are then tested to see how quickly they react.
To conduct the new study, rats were first trained for the tests and then taken to Brookhaven National Laboratory on Long Island in Upton, N.Y., where a collider produces the high-energy proton and heavy ion radiation particles that normally occur in space. The rats’ heads were exposed to varying levels of radiation that astronauts would normally receive during long-duration missions, while other rats were given sham exposures.
Once the rats returned to Johns Hopkins, they were tested every day for 250 days. The radiation-sensitive animals (19 of 46) all showed evidence of impairment that began at 50 to 60 days post–exposure and remained through the end of the study.
Lapses in attention occurred in 64 percent of the sensitive animals, elevations in impulsive responding occurred in 45 percent and slower reaction times occurred in 27 percent. The impairments were not dependent on radiation dose. Additionally, some of the rats didn’t recover at all from their deficits over time, while others showed some recovery over time.
The radiation-sensitive rats that received higher doses of radiation had a higher concentration of transporters for the neurotransmitter dopamine, which plays a role in vigilance and attention, says Catherine M. Davis, Ph.D., a postdoctoral fellow in the Department of Psychiatry and Behavioral Sciences and the study’s first author.
The dopamine transport system appears impaired in radiation-sensitive rats because the neurotransmitter is most likely not removed in the manner it should be for the brain to function properly, she says. Humans with genetic differences related to dopamine transport, she adds, have been shown to do worse on the type of mental fitness tests given to the astronauts and rats alike.
Davis says she wouldn’t want to see radiation-sensitive astronauts kept from future missions to the moon or Mars, but she would want those astronauts to be prepared to take special precautions to protect their brains, such as wearing extra shielding or not performing space walks.“As with other areas of personalized medicine, we would seek to create individual treatment and prevention plans for astronauts we believe would be more susceptible to cognitive deficits from radiation exposure,” she says.
Current astronauts are not as exposed to the damaging effects of radiation, Davis says, because the International Space Station flies in an orbit low enough that the Earth’s magnetic field continues to provide protection.
While the Johns Hopkins team studies the likely effects of radiation on the brain during a deep space mission, other NASA-funded research groups are looking at the potential effects of radiation on other parts of the body and on whether it increases cancer risks.
Apr 24, 2014 / 93 notes

neurosciencestuff:

(Image caption: A solar flare erupts on the far right side of the sun, in this image captured by NASA’s Solar Dynamics Observatory. The flare peaked at 6:34 p.m. EDT on March 12, 2014. Credit: NASA)

Some Astronauts at Risk for Cognitive Impairment

Johns Hopkins scientists report that rats exposed to high-energy particles, simulating conditions astronauts would face on a long-term deep space mission, show lapses in attention and slower reaction times, even when the radiation exposure is in extremely low dose ranges.

The cognitive impairments — which affected a large subset, but far from all, of the animals — appear to be linked to protein changes in the brain, the scientists say. The findings, if found to hold true in humans, suggest it may be possible to develop a biological marker to predict sensitivity to radiation’s effects on the human brain before deployment to deep space. The study, funded by NASA’s National Space Biomedical Research Institute, is described in the April issue of the journal Radiation Research.

When astronauts are outside of the Earth’s magnetic field, spaceships provide only limited shielding from radiation exposure, explains study leader Robert D. Hienz, Ph.D., an associate professor of behavioral biology at the Johns Hopkins University School of Medicine. If they take space walks or work outside their vehicles, they will be exposed to the full effects of radiation from solar flares and intergalactic cosmic rays, he says, and since neither the moon nor Mars have a planet-wide magnetic field, astronauts will be exposed to relatively high radiation levels, even when they land on these surfaces.

But not everyone will be affected the same way, his experiments suggest. “In our radiated rats, we found that 40 to 45 percent had these attention-related deficits, while the rest were seemingly unaffected,” Hienz says. “If the same proves true in humans and we can identify those more susceptible to radiation’s effects before they are harmfully exposed, we may be able to mitigate the damage.”

If a biomarker can be identified for humans, it could have even broader implications in determining the best course of treatment for patients receiving radiotherapy for brain tumors or identifying which patients may be more at risk from radiation-based medical treatments, the investigators note.

Previous research has tested how well radiation-exposed rats do with basic learning tasks and mazes, but this new Johns Hopkins study focused on tests that closely mimic the self-tests of fitness for duty currently used by astronauts on the International Space Station prior to mission-critical events such as space walks. Similar fitness tests are also used for soldiers, airline pilots and long-haul truckers.

In one such test, an astronaut sees a blank screen on a handheld device and is instructed to tap the screen when an LED counter lights up. The normal reaction time should be less than 300 milliseconds. The rats in the experiment are similarly taught to touch a light-up key with their noses and are then tested to see how quickly they react.

To conduct the new study, rats were first trained for the tests and then taken to Brookhaven National Laboratory on Long Island in Upton, N.Y., where a collider produces the high-energy proton and heavy ion radiation particles that normally occur in space. The rats’ heads were exposed to varying levels of radiation that astronauts would normally receive during long-duration missions, while other rats were given sham exposures.

Once the rats returned to Johns Hopkins, they were tested every day for 250 days. The radiation-sensitive animals (19 of 46) all showed evidence of impairment that began at 50 to 60 days post–exposure and remained through the end of the study.

Lapses in attention occurred in 64 percent of the sensitive animals, elevations in impulsive responding occurred in 45 percent and slower reaction times occurred in 27 percent. The impairments were not dependent on radiation dose. Additionally, some of the rats didn’t recover at all from their deficits over time, while others showed some recovery over time.

The radiation-sensitive rats that received higher doses of radiation had a higher concentration of transporters for the neurotransmitter dopamine, which plays a role in vigilance and attention, says Catherine M. Davis, Ph.D., a postdoctoral fellow in the Department of Psychiatry and Behavioral Sciences and the study’s first author.

The dopamine transport system appears impaired in radiation-sensitive rats because the neurotransmitter is most likely not removed in the manner it should be for the brain to function properly, she says. Humans with genetic differences related to dopamine transport, she adds, have been shown to do worse on the type of mental fitness tests given to the astronauts and rats alike.

Davis says she wouldn’t want to see radiation-sensitive astronauts kept from future missions to the moon or Mars, but she would want those astronauts to be prepared to take special precautions to protect their brains, such as wearing extra shielding or not performing space walks.

“As with other areas of personalized medicine, we would seek to create individual treatment and prevention plans for astronauts we believe would be more susceptible to cognitive deficits from radiation exposure,” she says.

Current astronauts are not as exposed to the damaging effects of radiation, Davis says, because the International Space Station flies in an orbit low enough that the Earth’s magnetic field continues to provide protection.

While the Johns Hopkins team studies the likely effects of radiation on the brain during a deep space mission, other NASA-funded research groups are looking at the potential effects of radiation on other parts of the body and on whether it increases cancer risks.

Apr 24, 2014 / 16,609 notes
domthephenom:

Bolt, Azula, and Appa @akosimrfresh @harro_2u #pomchi #pomeranian #chihuahua  (Taken with Instagram)

Oh my gawsh. They are so cute. I love how you named them after animated characters 👍👍👍
Apr 24, 2014 / 26 notes

domthephenom:

Bolt, Azula, and Appa @akosimrfresh @harro_2u #pomchi #pomeranian #chihuahua (Taken with Instagram)

Oh my gawsh. They are so cute. I love how you named them after animated characters 👍👍👍

domthephenom:

Bolt, Azula, and Appa @akosimrfresh @harro_2u #pomchi #pomeranian #chihuahua  (Taken with Instagram)
Apr 24, 2014 / 26 notes

domthephenom:

Bolt, Azula, and Appa @akosimrfresh @harro_2u #pomchi #pomeranian #chihuahua (Taken with Instagram)

Apr 24, 2014 / 505,718 notes

nojapanblog:

aelx:

ipoog:

daily reminder to click a button so you can give free food to a shelter!!

image

if every one of my followers did this, we could give more than 85 meals to less-fortunate animals. for free.

OMG please do this. I mean you just need to click on a button. Not more.

Apr 24, 2014 / 650,729 notes

tamaraneanprincessofgallifrey:

purplehairedfraek:

amozon28:

m7angela:

fallenark:

‘what doesn’t kill you makes you stronger’

what if i cut off your left leg

would that make you stronger

would it

image

image

image

image

this is a golden post

(via fuhersatangod)

My best guess —- they are at least in their 70s!!! Sooo adorable.
Apr 24, 2014 / 315,828 notes

My best guess —- they are at least in their 70s!!! Sooo adorable.

(via japanesecum)

izzyblack:

natureisthecult:

breatheghost:

unimpressedcats:

when your leg turns against you

I CAN’T STOP LAUGHING. OMFG.

this is 500% of what’s wrong with my life

Lmao
Apr 24, 2014 / 481,745 notes

izzyblack:

natureisthecult:

breatheghost:

unimpressedcats:

when your leg turns against you

I CAN’T STOP LAUGHING. OMFG.

this is 500% of what’s wrong with my life

Lmao

(via japanesecum)

srsfunny:

The Cost Of Healthcare In Americahttp://srsfunny.tumblr.com/
Apr 24, 2014 / 221 notes

srsfunny:

The Cost Of Healthcare In America
http://srsfunny.tumblr.com/

(via best-of-imgur)

Apr 24, 2014 / 757 notes

(via japanesecum)

Apr 24, 2014 / 153,684 notes

tylenold:

how do i lose weight quickly and easily and also how do i gain the ability to fly and breathe fire and how do i cheat death 

(via fuhersatangod)

Apr 24, 2014 / 1,432 notes

tsutchiee:

never seen a guren no yumiya cover done like this i mean seriously this is amazing

(via sugarelixir)

Apr 24, 2014 / 1,823 notes
Apr 24, 2014 / 132,547 notes

gobe:

Heart.Just.Broke.
Earth Day indeed.

(via kitsunesmelancholy)

Apr 24, 2014 / 37,226 notes

hiddleshabanera:

dragoniza:

”- Why don’t you smile? 

-Because I have an ugly smile.

-That’s impossible, when someone smiles, no matter what form have smile, or if your teeth are large, small, crooked… People just look beautiful when they smile, because we know that they are happy, and that’s what matters.”

teeth / smiles appreciation Animation

YOU FORGOT ONE 

image

(via kitsunesmelancholy)